In particular, the experiments show that MSA-PMCA fibrils display higher potency in seeding the endogenous oligodendroglial αSyn and promoting the redistribution of the oligodendroglial-specific phosphoprotein TPPP/p25α from the myelin sheath to the cell soma, as compared to PD-PMCA fibrils (Fig. 1). Here, TPPP is linked to Parkinson disease.