A local supplementation of BDNF together with another neurotrophic factor, fibroblast growth factor-2 (FGF-2), has been reported to attenuate SE-induced cell damage, increase hippocampal neural stem cell proliferation and neuronal differentiation, and reduce the aberrant aspects of epileptogenesis-associated neurogenesis, thereby ameliorating the epilepsy pathology and reducing the frequency and severity of spontaneous seizures [10]. The gene discussed is BDNF; the disease is epilepsy.