Till now, 9 types of IEIs have been reported with TM infections, that is, CD40 ligand deficiency (12 cases), STAT1 GOF (11 cases), STAT3 deficiency (7 cases), X-SCID (3 cases), IFN-γ receptor 1 deficiency (2 cases), CARD9 deficiency (2 cases), ADA deficiency (1 case), RelB deficiency (1 case) and NFKB2 deficiency (1 case) (Table 3). This evidence concerns the gene CARD9 and hyperinsulinemic hypoglycemia, familial, 4.