Overall, it has been found in previous studies on diseases other than ophthalmic diseases (mostly in cancer) that these miRNAs (hsa-mir-16, hsa-mir-142, hsa-mir-19a, hsa-mir-144, hsa-mir-195, hsa-mir-93, and hsa-mir-20a) play a role in inhibiting cell migration and invasion by regulating MMP-2 or -9. The gene discussed is MMP2; the disease is cancer.