Similar to systemic RLZ treatment, intra-vHPC infusion of RLZ increased the levels of GLAST and GLT-1 in the vHPC of both CD and HFD mice (Fig. 5i), alleviated HFD-induced depression-like behaviors in the SPT (Fig. 5j) and FST (Fig. 5k), and suppressed HFD-induced hyperactivity in vHPC→NAc glutamatergic transmission (Fig. 5l–n). This evidence concerns the gene SLC1A3 and depressive symptom measurement.