In humans, mutations in this gene cause the Fraser syndrome, a multisystem disorder involved in the structural adhesion of the skin ephitelium to its underlying mesenchyma52 and in pigs this gene has been proposed as candidate for developmental morphological traits such as presence of wattles53, The genes SOWAHB and EPHX1 showed somewhat similar association results, both affecting livelong growth traits and some fat deposition traits. Here, EPHX1 is linked to Fraser syndrome.