In the individual gene level, CPT-1A showed clustering with wild type BRCA-1, BRCA-2, PIK3CA, ATM, TP53, PTEN, RAD51, EGFR and CDH1, all moderate to high-penetrant genes known to be mutated in hereditary breast cancer (Supplementary Table 1). The gene discussed is PIK3CA; the disease is breast carcinoma.