In the fifth edition of the WHO classification, the diagnosis of adult IDH wild-type (IDHwt) diffuse gliomas is strongly based on molecular parameters, and even those that histologically do not present glioblastoma features but present one of three genetic parameters, TERT promoter mutation, EGFR gene amplification, or combined gain of entire chromosome 7 and loss of entire chromosome 10 [+ 7/ − 10], will also be classified as glioblastoma8. This evidence concerns the gene EGFR and glioblastoma.