It has been reported that during MS relapse, Levels of CXCL13 are higher and the positive correlations between these levels and other molecules that are essential for B-cell recruitment, survival, and maturation (B-cell activating factor (BAFF), IL-6, and IL-10) seem to be crucial to driving the B-cell response26,28,75,76. This evidence concerns the gene IL10 and myeloid sarcoma.