The bioinformatics analysis of miR-21 predicted targets suggested that multiple tumor suppressor genes, including programmed cell death 4 (PDCD4), tropomyosin (TPM1), PTEN, and Fork-head box O1 (FoxO1) related to apoptosis pathways, have miR-21 binding sites21,22,38. Here, FOXO1 is linked to neoplasm.