APOE and infection: In silico spatial ligand-receptor interaction analysis around the CVOs identified several significant ligand-receptor interactions upregulated during infection, including Clec1b-Klrb1c, involved in regulating NK cell-mediated cytolytic activity60, and Lpl-Lrp2, which are involved in ApoE-mediated cholesterol intake in neurons61 (Supplementary Fig. 5).