APOE and early-onset autosomal dominant Alzheimer disease: As the infection progresses, we noted an enrichment for genes associated with neurodegenerative disorders (e.g., Amyotrophic lateral sclerosis, Huntington disease, Parkinson disease, and Alzheimer’s disease) such as Apoe, Trem2, and Psen2 (Fig. 3Hleft, Supplementary Datas 9 and 10).