NOTCH1 and central nervous system cancer: By cotransfecting the miR-30c inhibitor and shRNA-Notch1 into A172 and U251 cells, we revealed that the miR-30c inhibitor could enhance the proliferation of glioma cells, while shRNA-Notch1 could attenuate this change (P < 0.05, T = 48h; P < 0.01, T = 72h) (Fig. 7A,B).