Figure 6A,B shows that inhibition of Notch1 expression can reduce the proliferation of A172 and U251 cells (P < 0.01, T = 48h; P < 0.01, T = 72h) and reduce the expression of Notch1 in glioma cells, which can significantly curtail cell migration and invasion (P < 0.01) (Fig. 6C,D). Here, NOTCH1 is linked to central nervous system cancer.