INS and Hypoglycemia: Male and female Agpat5flox/flox and Sim1Agpat5KO mice displayed identical body weight (Supplementary Fig. 1B), glucose tolerance (Supplementary Fig. 1C, D), insulin sensitivity (Supplementary Fig. 1E, F), and hypoglycemia-stimulated glucagon secretion (Supplementary Fig. 1G–J).