Within the endothelial cells, endothelial-1 (Endo-1) was the most abundant and enriched in the tumor (Fig. 4a, b, f), and characterized by an upregulation of tumor-associated genes (PVLAP, CA2, SPARC, INSR, and IGFBP7)48 (Fig. 4c, Supplementary Fig. 6b, d). The gene discussed is SPARC; the disease is neoplasm.