We further utilize bulk RNA-seq data and found a significant upregulation of SOX9, IL32, and SLC22A6 (PT2), and downregulation of SLC22A6/ SLC22A8 (PT1) in tumor compared to adjacent normal tissue (Supplementary Fig. 4d), confirming our cell origin hypothesis on PT2 cells. The gene discussed is SOX9; the disease is neoplasm.