Comparing the adjacent normal kidney tissue and the tumor, we detected two subpopulations: NK-1 and NK-2 (Fig. 2d), which were further annotated as CD56dim NK-1 cells (CD44, XCL1, XCL2, and KLRC1) and CD56bright NK-2 cells (FGFBP2, CX3CR1, and GZMB)29 (Supplementary Fig. 3a, h, i). This evidence concerns the gene GZMB and neoplasm.