Interestingly, a subcluster of Endo-1 was found almost exclusively in the tumor compartment (Fig. 4b), preferentially expressing known endothelial tip cell genes (KCNE3, DLL4, EDNRB, ANGPT2, and SERPINE1) (Supplementary Fig. 6b, f). This evidence concerns the gene KCNE3 and neoplasm.