The endothelial-5 (Endo-5) cluster showed a tumor-associated EC phenotype (IGFBP3, ENPP2, SEMA3G, TM4SF1, and TIMP3) (Fig. 4c; Supplementary Fig. 6b, d), high angiogenesis score (Fig. 4d) as well as similar upregulation of pathways related to blood vessel and circulatory development (Fig. 4g)48. Here, TIMP3 is linked to neoplasm.