The endothelial-5 (Endo-5) cluster showed a tumor-associated EC phenotype (IGFBP3, ENPP2, SEMA3G, TM4SF1, and TIMP3) (Fig. 4c; Supplementary Fig. 6b, d), high angiogenesis score (Fig. 4d) as well as similar upregulation of pathways related to blood vessel and circulatory development (Fig. 4g)48. The gene discussed is TM4SF1; the disease is neoplasm.