MyD88‐deficient mice have been found to be unresponsive to endotoxin.[20] Our group previously showed that MyD88 inhibitor attenuated obesity‐induced heart inflammation and injuries in mice.[27] To the best of our knowledge, this is the first time that the evaluation of the cardioprotective effects of MyD88 inhibition against DCM in both T1D and T2D mice was conducted. Here, MYD88 is linked to familial dilated cardiomyopathy.