MYD88 and obesity due to melanocortin 4 receptor deficiency: MyD88‐deficient mice have been found to be unresponsive to endotoxin.[20] Our group previously showed that MyD88 inhibitor attenuated obesity‐induced heart inflammation and injuries in mice.[27] To the best of our knowledge, this is the first time that the evaluation of the cardioprotective effects of MyD88 inhibition against DCM in both T1D and T2D mice was conducted.