MYD88 and diabetes mellitus: In support of such an approach, a recent study has shown that unlike TLR2/4‐MyD88 signaling, lack of TRIF had no impact on myocardial cytokines or neutrophil recruitment after ischemia/reperfusion, but myocardial apoptosis was significantly reduced in Trif knockout mice.[29] Therefore, determining whether TRIF inhibition offers added benefit in diabetes would be important in the future.