VCP and amyotrophic lateral sclerosis: We showed that ALS-related aberrant cytoplasmic IRTs are predicted to bind extensively to RNA-binding proteins (RBPs), including those that are mislocalized in ALS, and we proposed that a subset of cytoplasmic intronic sequences serve as “blueprints” for the hallmark protein mislocalization events in VCP-related ALS (Neumann et al. 2006; Tyzack et al. 2021).