More recently, Piper and colleagues showed that—while stimulation with the TLR7 agonist R848 can induce both IL-10 and IL-6 by healthy B cells—B cells from patients with the childhood autoimmune disease juvenile dermatomyositis (JDM), have a defect in IL-10 production and an increase in IL-6 production [65]. This evidence concerns the gene IL6 and autoimmune disease.