BCR and diffuse large B-cell lymphoma: In particular, consensus cluster classification has identified three subgroups of DLBCL based on gene expression and metabolic signatures: B cell receptor (BCR)–DLBCLs, which are characterized by the expression of genes encoding BCR signaling pathways; OxPhos-DLBCLs, which have high expression of genes involved in mitochondrial oxidative phosphorylation; and HR-DLBCLs, which have increased expression of genes involved in host inflammatory infiltration (12–14).