To find the combination of cytokines and chemokines that can better discriminate between patients with severe or non-severe P. vivax infections, the 13 quantified potential biomarkers were analyzed using the Gamlss Model in the confusion matrix of observed values, which showed that the joint analysis of the IL-4, IL-10, CCL2, and TGF-β shows significant differences between patients with severe and non-severe malaria due to P. vivax. The gene discussed is IL10; the disease is malaria.