As such, if novel structural LAM epitopes are created only by in vivo cultured cells then these potential epitopes will be missed and conversely, if recombinant Igs are screened from the memory B cell population of convalescent TB patients (e.g., A194-01, [22]), using cLAM as the target antigen in screening may miss Igs targeting uLAM epitopes not present in cLAM. This evidence concerns the gene CUBN and tuberculosis.