CUBN and tuberculosis: Recent advances to increase the sensitivity of LAM immunoassays have focused on developing Igs with improved sensitivity and specificity to TB LAM [22–26], sample preparation including pre-treatment to remove confounders [27–29], pre-enrichment of uLAM from urine prior to testing [30,31], amplifying the stripe signal [32] or highly sensitive immunoassay platforms [33–35].