Culturing pheochromocytomas from animal tumours led to the development of the rat PC12 cell line [17], which carries a Max gene variant, and the MPC [18] and derived MTT [19] mouse cell lines that originated from the Nf1 knockout mouse, as well as the more recent RS0 cell line from rats lacking SDHB [20]. Here, SDHB is linked to neoplasm.