Selecting for all patients aged <18 years, a yield of 15.4% can be distracted.10 Kühnish et al found 8 LP/P variants in 34 pediatric patients with DCM (24%) using a panel‐based NGS approach targeting 89 genes, which identified variants in TTN (1), TNNT2 (2), TNNI3 (1), MYH7 (1), MYBPC3 (1), and ACTC1 (1).25 In a recent study by Herkert et al, combining copy number variant analysis with stepwise trio-based ES yielded a diagnosis in >50% of pediatric DCM patients. The gene discussed is ACTC1; the disease is familial dilated cardiomyopathy.