What was noted, though, was that the majority of patients with low IgG levels at baseline or with combined hypogammaglobulinemia [IgG + (IgA and/or IgM)] at 3 months developed infections within the first 3 months, compared to patients free of these abnormalities (p < 0.05). The gene discussed is CD40LG; the disease is agammaglobulinemia.