A small fraction of patients also had multiple Ig abnormalities; at 3 months, 10/150 patients (7%) had deficient IgG and IgA levels, 10/151 patients (7%) had combined IgG and IgM deficiency, and 3/150 (2%) had pan hypogammaglobulinemia. Here, CD40LG is linked to agammaglobulinemia.