In another study, the changes in the heart failure with preserved ejection fraction (HFpEF) patients and mouse models m6A RNA methylation were investigated using the meRIP-seq and the results showed that m6A writers METTL3, METTL4 and KIAA1429; m6A eraser FTO; as well as the reader YTHDF2 were upregulated in HFpEF patients [112] while FTO expression was increased in HFpEF mice [96, 97]. Here, FTO is linked to heart failure.