It is a well-established fact that solid tumors are prone to hypoxic areas, and hypoxic tumors are particularly aggressive and chemically resistant Hypoxia is a potent inducer of PERK dependent eIF2α phosphorylation, consistent with PERK’s important pro-survival function in hypoxia-exposed cells, where PERK signaling increases tumor size, vascularization, and cell survival [53]. This evidence concerns the gene EIF2AK3 and neoplasm.