By contrast, BC-2 was differentially enriched in genes from the WNT, TGFb, and Hedgehog signaling pathways, as well as signatures associated with basal cell carcinoma and non-small cell lung cancer (Shin et al., 2011; Youssef et al., 2012; Chen et al., 2014; White and Lowry, 2015; Figure 1E). This evidence concerns the gene TGFB1 and non-small cell lung carcinoma.