Interestingly, several genes found to be differentially enriched in the BC-2 subpopulation, such as Tppp3, Tnfrsf12a, and Cav1 have been associated with severity or aggressiveness of squamous carcinoma in various organs (Yang et al., 2020; Hu et al., 2019; Xue et al., 2010). The gene discussed is TNFRSF12A; the disease is squamous cell carcinoma.