PBRM1 and clear cell renal carcinoma: Notably, PBRM1, a known tumour suppressor gene in renal clear cell carcinoma,24, 25, 26 was recurrently mutated in 27% (4/15) of our DPC cohort, which was significantly higher than that in the DUOAC (0%, p < .001) and AMPAC (7%, p < .001) cohorts.