PBRM1 and cancer: Given that all four PBRM1 mutations were loss‐of‐function mutations and PBRM1 has been reported in other cancer types (renal clear cell carcinoma) as a tumour suppressor,24, 25, 26, 27 we set out to understand the functions and potential mechanisms of PBRM1 alteration using shRNA targeted against PBRM1 in the HUTU‐80 cell line (the only cancer cell line of DUOAC) (Figure 3A,B).