A study using a comprehensive, single‐base resolution technique, Enhanced Reduced Representation Bisulfite Sequencing, to profile DNA methylation in benign prostate, prostate cancer and castrate resistant prostate cancer tissue identified a region in the first intron of the TBX1 gene that showed increasing levels of methylation with disease severity, together with increased gene expression.53 The gene discussed is TBX1; the disease is Familial prostate cancer.