Another top‐ranked lethal DMR, Cysteine Dioxygenase Type 1 (CDO1), is a potential tumour suppressor gene, which has shown promoter hypermethylation and gene silencing in a range of different cancers51 and notably showed that increased promoter methylation with BCR‐free survival in prostate cancer patients following RP.52 The gene discussed is BCR; the disease is prostate cancer.