This corroborates well with previous findings from colorectal cancer, which found that a low CD8+ lymphocyte/TB index correlated to lymph node metastasis, invasion into vessels, and unfavorable clinical outcome in a multivariate analysis and this index was proposed as a forthcoming prognostic tool for colorectal cancer patients (Lugli et al., 2009). Here, CD8A is linked to metastatic malignant neoplasm in the lymph nodes.