CD4 and neoplasm: Regarding intraepithelial tumoral infiltration, dense CD4+ cell infiltrate associated with poor tumor differentiation (phi = 0.45, p = .040) (Figure 3e,f), and higher CD4+ (phi = 0.46, p = .046) and CD20+ infiltration (phi = 0.69, p = .003) correlated with advanced tumor stage (Figure 3g,h).