In this pathway, hypertrophy stimulation will increase plasma calcium levels and activate can dephosphorylate NFAT3, after which the dephosphorylated NFAT3 enters the nucleus and interacts with GATA4 to activate multiple genes related to myocardial hypertrophy (Vega et al., 2003). This evidence concerns the gene GATA4 and cardiac hypertrophy.