MAPK3 and Chronic colitis: Some researchers, to reveal the curative effect of andrographolide derivatives, studied how andrographolide sulfonates (the main components of the xi phlogistic flat) for chronic colitis affect specific pathways, tested the 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced chronic colitis model, and discovered that the NF-κB signaling pathway is also activated by chance, and the results demonstrated that the level of P-P65 decreased and the activation of P38 and ERK1/2 in the colon tissue was inhibited after the intervention of andrographolide sulfonates (Gao et al., 2020).