ATXN3 and Friedreich ataxia: The dentate nuclei (DN) of the cerebellum, which could project output to non-motor areas of the prefrontal and posterior parietal cortex (Bostan et al., 2013), are characteristic sites of neurodegeneration in several SCD subtypes such as SCA3 and Friedreich’s ataxia (Scherzed et al., 2012; Harding et al., 2016; Koeppen, 2018).