While these studies strongly indicate a role for the MCH system in modulating stress, anxiety and depression—and suggest a potential clinical application for MCHR1 antagonists in the treatment of mood disorders—a 2006 study by Basso et al. (2006) failed to replicate many of the previously reported effects of certain MCHR1 antagonists in several of the same behavioral assays. The gene discussed is PMCH; the disease is major depressive disorder.