The interaction between ROCK1 and these transcripts can affect development of different types of cancers as well as a number of non-malignant conditions such as metabolic syndrome, diabetes, acute lung injury, pneumonia, endometriosis, non-alcoholic fatty liver disease, cerebral ischemia/reperfusion injury, myocardial Infarction, osteoporosis and atherosclerosis. This evidence concerns the gene ROCK1 and brain ischemia.