The interaction between ROCK1 and these transcripts can affect development of different types of cancers as well as a number of non-malignant conditions such as metabolic syndrome, diabetes, acute lung injury, pneumonia, endometriosis, non-alcoholic fatty liver disease, cerebral ischemia/reperfusion injury, myocardial Infarction, osteoporosis and atherosclerosis. The gene discussed is ROCK1; the disease is metabolic dysfunction-associated steatotic liver disease.