With the occurrence of septic shock as the dependent variable, the above discrete indicators (highest HR ≥ 105 beats/min, GCS score≤14 points, Lac ≥ 5.75 mmol/L, SCr ≥ 116.5 umol/L, PCT ≥ 41.47 ug/L, CRP ≥ 222.5 mg/L, highest K+ ≥ 4.35 mmol/L, Alb ≤ 18.15 g/L, pH ≤ 7.28,PaO2/FiO2 ≤ 171.75 mmHg, SOFA score ≥8.88 points, APACHE-II score ≥22.5 points) were included in the multivariate Logistic regression equation for analysis (Table 4). This evidence concerns the gene CRP and septic shock.