The interaction of the SIRT1 gene rs12415800 genotype and diagnosis of FA values in the depression (GG), depression (AG/AA), control (GG), and control (AG/AA) groups showed that there was a significant difference in one cluster, which contained the left anterior thalamus radiation (2.0%) and left cingulate fasciculus (1.3%) (MNI coordinates X = −20, Y = −54, Z = 43; voxel = 36; P = 0.032) (Figure 1). The gene discussed is SIRT1; the disease is major depressive disorder.