Mutations in FOXP3 lead to IPEX syndrome, which should be considered in males with the following clinical signs: early-onset IBD, endocrinopathy (most commonly type 1 diabetes mellitus and autoimmune thyroid disease), and dermatitis (most commonly eczema) (78). This evidence concerns the gene FOXP3 and immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome.