Although the resistance of Dendrobium polysaccharides to viral infection is rarely reported, we speculate that DVP-1 can prevent viral infection by activating body immunity based on the effective results of the DVP-1 promotion of the expression of key proteins and phosphorylation of the TLR4/MyD88/NF-κB pathway in our previous study and the results from this study. This evidence concerns the gene NFKB1 and viral infectious disease.