Intriguingly, in MS, several rare DC subsets expressing CD8, CD103, dendritic cell endocytic receptor (DEC205), B- and T-lymphocyte attenuator (BTLA) or secreting interleukin (IL)-10, IL-27, IL-35 might become the potential tolDC subsets that induce Tregs. Here, IL27 is linked to myeloid sarcoma.