LAG3 and immune system disorder: Due to the expression level of LAG-3 in MS patients and the pathological characteristics of immune diseases, it can be speculated that the LAG-3/MHC-II axis is involved in DC-Treg cell crosstalk in MS/EAE and that the LAG-3/TCR/MHC-II inhibitory feedback loop mediates DC-Treg cell interactions and plays a protective role in MS/EAE.