The mechanism of primary resistance includes lack of tumor immunogenicity (35), T cell exclusion (36), lack of interferon responsiveness (37), epidermal growth factor receptor (EGFR) mutations and anaplastic lymphoma kinase(ALK) rearrangements (38), local immunosuppressive factors in tumor microenvironment (39) and other factors (Figure 2). This evidence concerns the gene EGFR and neoplasm.