Furthermore, a study aimed at analyzing the prognostic value of PD-L1 in CRC cells and tumor cell infiltrates (TILs) revealed that high expression of PD-1 and PD-L1 was associated with a better prognosis in colorectal cancer patients and TILs-PD-1 may be an independent prognostic factor for OS and disease-free survival (DFS) in CRC patients (144). This evidence concerns the gene CD274 and colorectal carcinoma.