In this study, we identified that Nsp14 increases nuclear translocation of p65 and induces the expression of NF-κB’s downstream cytokines, such as IL-6 and IL-8, which have also been detected in lung tissues of COVID-19 patients (5, 32) and animal models of SARS-CoV-2 infection (7). The gene discussed is NFKB1; the disease is COVID-19.