TP53 and hepatocellular carcinoma: Venn plot displayed that 95 agents were intersected, which implied that patients in the CRGPI-high subgroup or who belong to cluster C may benefit more from most kinds of chemotherapies (Figure 7A). In addition, we used GSEA to further explore the activity of pathway signaling in differential expressed genes of TCGA-LIHC and found that the activity of the p53 and NF-kappa B signaling pathways were upregulated in the HCC patients (Figure 7B).