CDKN2A and hepatocellular carcinoma: Among them, CDKN2A had the highest mutation frequency (2.55%) and the highest deep deletion rate (5.67%), while LIAS (1.98%) and DLD (1.7%) had a higher amplification, and FDX1 did not have any mutations or CNV (Figure 1A). Since the ICGC database had relatively complete clinical information and large patient samples, it was applied to examine the mRNA expression of 10 CRGs in HCC.