As expected from the clinical definition, age-adjusted sIg levels (IgG, IgA, and IgG subclasses) were significantly lower in PAD (both ‘CVID’ and ‘other PAD’) compared to non-PID DCs and non-lymphoid-PID patients (p < 0.001) (Supplementary Figure 1). The gene discussed is CD79A; the disease is peripheral arterial disease.