PD-L1 expression Tumor Proportion Score (TPS) ≥ 50% also had a higher pCR rate compared to those with TPS <50% (100.0%, 95% CI: 77.7%-100.0%, I2 = 0% vs 47.9%, 95% CI: 36.3%-59.5%, I2 = 0%; P < 0.001), while no difference was observed between TPS ≥1% and <1% (65.9%, 95% CI: 28.8%-100%, I2 = 80% vs 50.0%, 95% CI: 30.8%-69.2%, I2 = 45%; P = 0.46) (Figure 5). This evidence concerns the gene CD274 and neoplasm.