Further analyses of individual grade ≥3 TRAEs (Figure 3) showed that nICRT was associated with more lymphopenia (37.8%, 95% CI: 0.0%-89.9%, I2 = 98% vs 0.2%, 95% CI: 0.0%-1.3%, I2 = 13%; P = 0.05) and nausea (5.4%, 95% CI: 0.8%-12.5%, I2 = 39% vs 0.1%, 95% CI: 0.0%-0.9%, I2 = 0%; P = 0.01) than nICT; other individual grade ≥3 TRAEs including neutropenia, thrombocytopenia, anemia, AST/ALT increasing, vomiting, diarrhea, hypokalemia, and pneumonitis/pneumonia were comparable between nICRT and nICT (P > 0.05 for each comparison). The gene discussed is GPT; the disease is lymphopenia.