Lower frequency of cytokine-producing memory CD8+ and CD4+ T cells was found in HIV-infected patients with Cryptococcus meningitis (CM), but their numbers were increased with more polyfunctional IL-2+/IL-17+ CD4+ T cells and IL-2+ CD8+ T cells following antiretroviral therapy (ART) in CM-associated immune reconstitution inflammatory syndrome (CM-IRIS) (161) patients, suggesting the pathological role of cryptococcal memory T cells under certain conditions. Here, IL2 is linked to cutaneous mastocytosis.