During systemic Candida infection, the protective role of Dectin-1 was fungal strain-specific, possibly due to variable adaptation of Candida albicans strains in vivo, including the changes in the microbiota of mice due to different mouse facilities, with changes in the cell wall components and high chitin in the cell wall masks the dependability on Dectin-1 recognition (36). The gene discussed is CLEC7A; the disease is candidiasis.