Based on their cytokine secretion and functions during fungal infections (84, 85), T cells are classified into Th1 (IFNγ, GM-CSF, and TNFα), Th17 (IL-17A/F), Th22 (IL-22), Th2 (IL-4 and IL-13), Th9 (IL-9 and IL-10), Treg (IL-10 and TGFβ), and Tr1 (IL-10). This evidence concerns the gene TNF and fungal infectious disease.