CYP1B1 (cytochrome P450 family 1 subfamily B member 1) enzyme is a member of the cytochrome P450 (CYP450) family that plays a role in the conversion of procarcinogens to carcinogens, in addition, it is involved in the process of CRC progression (67). The gene discussed is CYP1B1; the disease is colorectal carcinoma.