ISG20 and cancer: By analyzing the ISG20 mutation profile in 32 types of cancer based on data obtained from TCGA, we found that STAD (stomach adenocarcinoma) had the highest mutational frequency, with 3.64% of 440 cases possessing a mutation, followed by SARC (3.53% of 255 cases), whereas BLGG (brain lower grade glioma) had the lowest frequency of mutations (0.19% of 514 cases) (Figure ​6A).