By analyzing the DNMIVD database, we found that ISG20 promoter methylation was significantly lower in BLCA, READ, and THCA tumor tissues compared to the matching normal tissue (Figures 4A–C), while higher in BRCA, LUSC, KIRC, and PAAD (Figures 4D–G). This evidence concerns the gene ISG20 and pancreatic adenocarcinoma.