Due to the indispensability of antiviral processes and anti-tumor responses in the immune system, the correlation between ISG20 expression and immune infiltration levels of pan-cancer was analyzed, and we revealed significant correlations between ISG20 expression and immune lymphocytes, chemokine, receptors, immunoinhibitors, immunostimulators, and MHC molecules in all cancer types, highlighting a potential antiviral/anti-SARS-CoV-2 role. This evidence concerns the gene ISG20 and cancer.