As a result, GPR84, NCF2, HK3, LILRB2, and CCL18 significantly affected the overall survival (OS) of GBM patients (multivatiate Cox p < 0.05) (Figure 2A), of which the protein level of GPR84 and NCF2 was significantly increased in the tumor core region (Figure 2E, F, Supplementary Figure 6C). This evidence concerns the gene GPR84 and neoplasm.