As a result, GPR84, NCF2, HK3, LILRB2, and CCL18 significantly affected the overall survival (OS) of GBM patients (multivatiate Cox p < 0.05) (Figure 2A), of which the protein level of GPR84 and NCF2 was significantly increased in the tumor core region (Figure 2E, F, Supplementary Figure 6C). The gene discussed is HK3; the disease is glioblastoma.