In COAD patients with GEO, the infiltration levels of aDCs, B cells, CD8+ T cells, DCs, macrophages, neutrophils, T helper cells, Tfh, Th2 cells, and TIL in tumor tissues of high-risk patients were higher than those of low-risk patients, suggesting that our risk model could reflect the immune infiltration of patients. The gene discussed is CD8A; the disease is neoplasm.