Fan et al. (9) employed a multivariate logistic regression method to reveal that age, diabetes, New York Heart Association (NYHA) classification, estimated glomerular filtration rate (eGFR), highly sensitive C-reactive protein (hs-CRP), and urinary angiotensinogen (uAGT) were independently associated with AKI development in HF patients. The gene discussed is CRP; the disease is acute kidney injury.